Tuesday, October 25, 2011

Multiple inflammatory markers

Inflammatory markers such as c-reactive protein (CRP) of adult obesity-related, but the correlation among children is not clear. In the United States 1999?2006 years in health and nutrition survey, researchers have to cross the 1~17sui children analysis, the purpose is to evaluate a variety of inflammatory markers and the relationship between children's weight status. Study assumptions as children's weight increased, inflammatory markers of level increases. &Nbsp; age <2 aged Shi under heavy high index,  2 aged Shi under weight index (BMI), will WINS children is divided into very obesity (  No. 9900 min bit number), obesity (< 99th and   No. 9500 min bit number), excessive obesity (< 95th and   No. 8500 min bit number), normal weight (> 5th to   No. 8500 min bit number) four class. CRP main monitoring indicators for high responsiveness and absolute neutrophil counts, another indicator is ratio of ferritin and transferrin. Applying Cox proportional opportunities model to assess abnormal weight-related inflammatory markers of risk. &Nbsp; showed that in very obese children, from 3~5sui to 15~17sui, significantly increase the risk of CRP>1.0 mg/L  , (P<0.01), the risk of abnormal neutrophil count began to increase when the 6~8sui (P=0.049), ferritin and transferrin ratio abnormal increased risk at di9~11 beginning at the age (P<0.001). &Nbsp; thus, the researchers said a variety of inflammatory markers associated with children's weight status increased strongly, the Association from the age of 3. Elevated inflammatory markers and the young are very obese children is particularly relevant because, inflammation of blood vessels can lead to long-term, cumulative damage.  This warrants another study on longitudinal design. Original summary: Pediatrics 2010; DOI:10.1542/peds.2009-2182www.cmt.com.cn  

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